Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor

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Limón, David, Jiménez-Newman, Claire, Calpena, Ana C., Gonzalez-Campo, Arántzazu, Amabilino, David A. and Pérez-García, Lluïsa (2017) Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor. Chemical Communications, 53 . pp. 1433-1434. ISSN 1364-548X

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Official URL: http://pubs.rsc.org/en/Content/ArticleLanding/2017/CC/C6CC09392B#!divAbstract

Abstract

Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug release from the gel. Drug release and skin permeation experiments show its potential for topical administration.

Item Type:	Article
RIS ID:	https://nottingham-repository.worktribe.com/output/851882
Schools/Departments:	University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number:	https://doi.org/10.1039/C6CC09392B
Depositing User:	Bramwell, Roseanna
Date Deposited:	24 Mar 2017 15:54
Last Modified:	04 May 2020 18:38
URI:	https://eprints.nottingham.ac.uk/id/eprint/41547

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