Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women

Alshammari, G. and Khan, Raheela and Brameld, John M. and Amer, Saad A. and Lomax, Michael A. (2017) Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women. European Review for Medical and Pharmacological Sciences, 21 (5). pp. 1099-1105. ISSN 2284-0729

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Abstract

OBJECTIVE: The pathogenesis of polycystic ovary syndrome (PCOS), a common endocrine disease and metabolic disturbance, is still unknown. The aim of the study was to investigate whether patients with PCOS display increased expression of inflammatory markers in adipose tissue.

PATIENTS AND METHODS: Two groups of women were investigated, those diagnosed with PCOS (n = 8) and age and BMI-matched normal women (n = 12). Their age was between 20-45 years and all subjects were apparently healthy and did not take any medications. Adipose tissue levels of mRNA of inflammatory markers were determined by use of real-time PCR.

RESULTS: There were no differences between obese patients and obese PCOS in levels of adipocytokines.

CONCLUSIONS: There were no effects of PCOS on the expression of any of the adipocytokines genes measured in subcutaneous adipose tissue.

Item Type: Article
Keywords: Polycystic ovary syndrome, Insulin resistance, Inflammation
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
University of Nottingham, UK > Faculty of Science > School of Biosciences
University of Nottingham, UK > Faculty of Science > School of Biosciences > Division of Nutritional Sciences
Depositing User: Brameld, John
Date Deposited: 24 Mar 2017 08:46
Last Modified: 13 Oct 2017 17:51
URI: http://eprints.nottingham.ac.uk/id/eprint/41529

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