3D printed fluidics with embedded analytic functionality for automated reaction optimisation

Capel, Andrew J. and Wright, Andrew and Harding, Matthew J. and Weaver, George W. and Li, Yuqi and Harris, Russell A. and Edmondson, Steve and Goodridge, Ruth D. and Christie, Steven D.R. (2017) 3D printed fluidics with embedded analytic functionality for automated reaction optimisation. Beilstein Journal of Organic Chemistry, 13 . pp. 111-119. ISSN 1860-5397

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Abstract

Additive manufacturing or ‘3D printing’ is being developed as a novel manufacturing process for the production of bespoke micro- and milliscale fluidic devices. When coupled with online monitoring and optimisation software, this offers an advanced, customised method for performing automated chemical synthesis. This paper reports the use of two additive manufacturing processes, stereolithography and selective laser melting, to create multifunctional fluidic devices with embedded reaction monitoring capability. The selectively laser melted parts are the first published examples of multifunctional 3D printed metal fluidic devices. These devices allow high temperature and pressure chemistry to be performed in solvent systems destructive to the majority of devices manufactured via stereolithography, polymer jetting and fused deposition modelling processes previously utilised for this application. These devices were integrated with commercially available flow chemistry, chromatographic and spectroscopic analysis equipment, allowing automated online and inline optimisation of the reaction medium. This set-up allowed the optimisation of two reactions, a ketone functional group interconversion and a fused polycyclic heterocycle formation, via spectroscopic and chromatographic analysis.

Item Type: Article
Keywords: 3D printing; Inline reaction analysis; Reaction optimisation; Selective laser melting; Stereolithography
Schools/Departments: University of Nottingham, UK > Faculty of Engineering
Identification Number: 10.3762/bjoc.13.14
Depositing User: Eprints, Support
Date Deposited: 22 Mar 2017 11:14
Last Modified: 12 Oct 2017 22:28
URI: http://eprints.nottingham.ac.uk/id/eprint/41469

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