Bioprinting using mechanically robust core-shell cell-laden hydrogel strands

Mistry, Pritesh and Aied, Ahmed and Alexander, Morgan R. and Shakesheff, Kevin and Bennett, Andrew and Yang, Jing (2017) Bioprinting using mechanically robust core-shell cell-laden hydrogel strands. Macromolecular Bioscience . ISSN 1616-5195

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Abstract

The strand material in extrusion-based bioprinting determines the microenvironments of the embedded cells and the initial mechanical properties of the constructs. One unmet challenge is the combination of optimal biological and mechanical properties in bioprinted constructs. Here, a novel bioprinting method that utilises core-shell cell-laden strands with a mechanically robust shell and an extracellular matrix (ECM)-like core has been developed. Cells encapsulated in the strands demonstrate high cell viability and tissue-like functions during cultivation. This process of bioprinting using core-shell strands with optimal biochemical and biomechanical properties represents a new strategy for fabricating functional human tissues and organs.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: P. Mistry, A. Aied, M. Alexander, K. Shakesheff, A. Bennett, J. Yang, Macromol. Biosci. 2017, 1600472, which has been published in final form at doi:10.1002/mabi.201600472. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences
University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: 10.1002/mabi.201600472
Depositing User: Yang, Jing
Date Deposited: 22 Mar 2017 11:36
Last Modified: 23 Mar 2017 08:43
URI: http://eprints.nottingham.ac.uk/id/eprint/41404

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