Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge

Savers, Amélie and Rasid, Orhan and Parlato, Marianna and Brock, Matthias and Jouvion, Gregory and Ryffel, Bernhard and Cavaillon, Jean-Marc and Eberl, Gerard and Ibrahim-Granet, Oumaïma (2016) Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge. PLoS ONE, 11 (4). e0153829. ISSN 1932-6203

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Available under Licence Creative Commons Attribution.
Download (1MB) | Preview

Abstract

Phagocytes restrict the germination of Aspergillus fumigatus conidia and prevent the establishment of invasive pulmonary aspergillosis in immunecompetent mice. Here we report that immunecompetent mice recovering from a primary A. fumigatus challenge are protected against a secondary lethal challenge. Using RAGγc knock-out mice we show that this protection is independent of T, B and NK cells. In protected mice, lung phagocytes are recruited more rapidly and are more efficient in conidial phagocytosis and killing. Protection was also associated with an enhanced expression of CXCR2 and Dectin-1 on bone marrow phagocytes. We also show that protective lung cytokine and chemokine responses are induced more rapidly and with enhanced dynamics in protected mice. Our findings support the hypothesis that following a first encounter with a non-lethal dose of A. fumigatus conidia, the innate immune system is primed and can mediate protection against a secondary lethal infection.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number: 10.1371/journal.pone.0153829
Depositing User: Eprints, Support
Date Deposited: 14 Mar 2017 09:32
Last Modified: 13 Oct 2017 01:29
URI: http://eprints.nottingham.ac.uk/id/eprint/41290

Actions (Archive Staff Only)

Edit View Edit View