Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study

Barratt, Eleanor L. and Tewarie, Prejaas K. and Clarke, Margareta A. and Hall, Emma L. and Gowland, Penny A. and Morris, Peter G. and Francis, Susan T. and Evangelou, Nikos and Brookes, Matthew J. (2017) Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study. Human Brain Mapping, 38 (5). pp. 2441-2453. ISSN 1097-0193

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Abstract

Multiple sclerosis (MS) is a debilitating disease commonly attributed to degradation of white matter myelin. Symptoms include fatigue, as well as problems associated with vision and movement. Although areas of demyelination in white matter are observed routinely in patients undergoing MRI scans, such measures are often a poor predictor of disease severity. For this reason, it is instructive to measure associated changes in brain function. Widespread white-matter demyelination may lead to delays of propagation of neuronal activity, and with its excellent temporal resolution, magnetoencephalography can be used to probe such delays in controlled conditions (e.g., during a task). In healthy subjects, responses to visuomotor tasks are well documented: in motor cortex, movement elicits a localised decrease in the power of beta band oscillations (event-related beta desynchronisation) followed by an increase above baseline on movement cessation (post-movement beta rebound (PMBR)). In visual cortex, visual stimulation generates increased gamma oscillations. In this study, we use a visuomotor paradigm to measure these responses in MS patients and compare them to age- and gender-matched healthy controls. We show a significant increase in the time-to-peak of the PMBR in patients which correlates significantly with the symbol digit modalities test: a measure of information processing speed. A significant decrease in the amplitude of visual gamma oscillations in patients is also seen. These findings highlight the potential value of electrophysiological imaging in generating a new understanding of visual disturbances and abnormal motor control in MS patients.

Item Type: Article
Keywords: multiple sclerosis; post-movement beta rebound; visual gamma; MEG; visuomotor abnormalities; neuronal oscillations
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
University of Nottingham, UK > Faculty of Science > School of Physics and Astronomy
Identification Number: 10.1002/hbm.23531
Depositing User: Eprints, Support
Date Deposited: 28 Feb 2017 14:48
Last Modified: 12 Aug 2017 08:54
URI: http://eprints.nottingham.ac.uk/id/eprint/40919

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