Canine idiopathic chronic hepatitis

Bexfield, Nicholas (2017) Canine idiopathic chronic hepatitis. Veterinary Clinics of North America: Small Animal Practice, 47 (3). pp. 645-663. ISSN 1878-1306

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Abstract

Canine idiopathic hepatitis is a common disease, categorized histologically by presence of hepatocellular apoptosis or necrosis, a variable mononuclear or mixed inflammatory cell infiltrate, regeneration and fibrosis.

Clinical signs are vague and non-specific, but there are known breed, age and gender predispositions.

Results of clinical pathology are non-specific, but usually include elevations in liver enzymes and function impairment; a liver biopsy is required for diagnosis.

Management involves around the use of an anti-inflammatory dose of glucocorticoids and other supportive and symptomatic therapies including ursodeoxycholic acid, antioxidants, diuretics, and diet.

The prognosis is variable, but there are known prognostic indicators, especially the presence of portal hypertension

Item Type: Article
Keywords: Idiopathic; Hepatitis; Canine; Diagnosis; Management; Prognosis
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: 10.1016/j.cvsm.2016.11.012
Depositing User: Bexfield, Nicholas
Date Deposited: 28 Feb 2017 08:52
Last Modified: 13 Oct 2017 01:42
URI: http://eprints.nottingham.ac.uk/id/eprint/40734

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