A distinct bacterial dysbiosis associated skin inflammation in ovine footrot

Maboni, G. and Blanchard, Adam M. and Frosth, S. and Stewart, Ceri E. and Emes, Richard D. and Tötemeyer, Sabine (2017) A distinct bacterial dysbiosis associated skin inflammation in ovine footrot. Scientific Reports, 7 . 45220/1-45220/11. ISSN 2045-2322

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Abstract

Ovine footrot is a highly prevalent bacterial disease caused by Dichelobacter nodosus and characterised by the separation of the hoof horn from the underlying skin. The role of innate immune molecules and other bacterial communities in the development of footrot lesions remains unclear. This study shows a significant association between the high expression of IL1β and high D. nodosus load in footrot samples. Investigation of the microbial population identified distinct bacterial populations in the different disease stages and also depending on the level of inflammation. Treponema (34%), Mycoplasma(29%) and Porphyromonas (15%) were the most abundant genera associated with high levels of inflammation in footrot. In contrast, Acinetobacter (25%), Corynebacteria (17%) and Flavobacterium (17%) were the most abundant genera associated with high levels of inflammation in healthy feet. This demonstrates for the first time there is a distinct microbial community associated with footrot and high cytokine expression.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: 10.1038/srep45220
Depositing User: Eprints, Support
Date Deposited: 28 Mar 2017 11:59
Last Modified: 12 Oct 2017 22:18
URI: http://eprints.nottingham.ac.uk/id/eprint/40730

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