Novel strategies for assessing platelet reactivity

Algahtani, Mohammad and Heptinstall, Stan (2017) Novel strategies for assessing platelet reactivity. Future Cardiology, 13 (1). pp. 33-47. ISSN 1479-6678

[img] PDF - Repository staff only until 19 December 2017. - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (480kB)

Abstract

There are many approaches to assessing platelet reactivity and many uses for such measurements. Initially, measurements were based on the ability of platelets separated from other blood cells to aggregate together following activation with an appropriate ‘aggregating agent’. Later, measurements of platelet aggregation in blood itself were performed, and this led to a point-of-care approach to platelet function testing. Measurement of secretory activity through the appearance of the activation marker P-selectin on platelets now provides an alternative approach, which enables remote testing.

Measurement of vasodilator-stimulated phosphoprotein phosphorylation is also moving toward application in situations remote from the testing laboratory. Here we provide an overview of the various approaches that are now available, assess their advantages and disadvantages, and describe some of the clinical situations in which they are being used.

Item Type: Article
Keywords: aspirin ; flow cytometry ; light transmission aggregometry ; LTA ; MEA ; multiplate electrode aggregometry ; P-selectin ; P2Y12 antagonists ; platelet aggregation ; platelet reactivity ; VASP phosphorylation ; VerifyNow
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Clinical Neuroscience
Identification Number: 10.2217/fca-2016-0054
Depositing User: Eprints, Support
Date Deposited: 10 Feb 2017 13:43
Last Modified: 25 Jul 2017 13:13
URI: http://eprints.nottingham.ac.uk/id/eprint/40527

Actions (Archive Staff Only)

Edit View Edit View