Dual infection with bluetongue virus serotypes and first time detection of serotype 5 in India

Hemadri, D. and Maan, Sushila and Rao, Prarthana Nagaraj and Putty, Kalyani and Krishnajyothi, Yadlapati and Reddy, G. Hanmanth and Kumar, Vinay and Batra, Kanisht and Reddy, Y. Vishnuvardhan and Maan, Narender Singh and Reddy, Yella Narasimha and Singh, Karam Pal and Shivachandra, Sathish Bhadravati and Hegde, Nagendra and Rahman, Habibur and Mertens, Peter P.C. (2017) Dual infection with bluetongue virus serotypes and first time detection of serotype 5 in India. Transboundary and Emerging Diseases, 64 (6). pp. 1912-1917. ISSN 1865-1682

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Abstract

Bluetongue is endemic in India and has been reported from most Indian states. Of late, the clinical disease is most frequently seen in the states of Andhra Pradesh, Telangana (erstwhile Andhra Pradesh state), Tamil Nadu and Karnataka. Our analysis of diagnostic samples from bluetongue outbreaks during 2010–2011 from the state of Karnataka identified bluetongue virus (BTV) serotype 5 (BTV-5) for the first time in India. One of the diagnostic samples (CH1) and subsequent virus isolate (IND2010/02) contained both BTV-2 and BTV-5. Segment 2 (seg-2) sequence data (400 bp: nucleotides 2538–2921) for IND2010/02-BTV5, showed 94.3% nucleotide identity to BTV-5 from South Africa (Accession no. AJ585126), confirming the virus serotype and also indicating that Seg-2 was derived from a Western topotype, which is in contrast to serotype 2, that belongs to an Eastern topotype. BTV-5 has been recently reported from Africa, China, French islands and the Americas. Although the exact source of the Indian BTV-5 isolate is still to be confirmed, recent identification of additional exotic serotypes in India is of real concern and might add to the severity of the disease seen in these outbreaks.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Hemadri, D., Maan, S., Chanda, M. M., Rao, P. P., Putty, K., Krishnajyothi, Y., Reddy, G. H., Kumar, V., Batra, K., Reddy, Y. V., Maan, N. S., Reddy, Y. N., Singh, K. P., Shivachandra, S. B., Hegde, N. R., Rahman, H. and Mertens, P. P. C. (2016), Dual Infection with Bluetongue Virus Serotypes and First-Time Isolation of Serotype 5 in India. Transboundary and Emerging Diseases. doi: 10.1111/tbed.12589, which has been published in final form at http://dx.doi.org/10.1111/tbed.12589. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: bluetongue; serotype 5; India; topotype
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: 10.1111/tbed.12589
Depositing User: Eprints, Support
Date Deposited: 09 Feb 2017 11:49
Last Modified: 16 Nov 2017 18:04
URI: http://eprints.nottingham.ac.uk/id/eprint/40481

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