Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos

Sepulveda-Rincon, Lessly P. and Solanas, Edgar del Llano and Serrano-Revuelta, Elisa and Ruddick, Lydia and Maalouf, Walid E. and Beaujean, Nathalie (2016) Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos. Theriogenology, 86 (1). pp. 91-98. ISSN 1879-3231

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Abstract

Despite ongoing research in a number of species, the efficiency of embryo production by nuclear transfer remains low. Incomplete epigenetic reprogramming of the nucleus introduced in the recipient oocyte is one factor proposed to limit the success of this technique. Nonetheless, knowledge of reprogramming factors has increased—thanks to comparative studies on reprogramming of the paternal genome brought by sperm on fertilization—and will be reviewed here. Another valuable model of reprogramming is the one obtained in the absence of sperm fertilization through artificial activation—the parthenote—and will also be introduced. Altogether the objective of this review is to have a better understanding on the mechanisms responsible for the resistance to reprogramming, not only because it could improve embryonic development but also as it could benefit therapeutic reprogramming research.

Item Type: Article
Keywords: Oocyte; Nuclear transfer; Embryonic genome activation; Histones posttranslational modifications; DNA methylation
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Child Health, Obstetrics and Gynaecology
Identification Number: 10.1016/j.theriogenology.2016.04.022
Depositing User: Eprints, Support
Date Deposited: 07 Feb 2017 09:41
Last Modified: 28 Apr 2017 19:36
URI: http://eprints.nottingham.ac.uk/id/eprint/40374

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