Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease

Stöger, Reinhard and Scaife, Paula and Shephard, Freya and Chakrabarti, Lisa (2017) Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease. npj Parkinson's Disease, 3 (6). pp. 1-6. ISSN 2373-8057

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Available under Licence Creative Commons Attribution.
Download (404kB) | Preview

Abstract

5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-linked immunosorbent assay in DNA from post-mortem cerebella of individuals with Parkinson’s disease and age-matched controls. 5-methylcytosine levels showed no significant differences between Parkinson’s disease and control DNA sample sets. In contrast, median 5-hydroxymethylcytosine levels were almost twice as high (p < 0.001) in both male and female Parkinson’s disease individuals compared with controls. The distinct epigenetic profile identified in cerebellar DNA of Parkinson’s disease patients raises the question whether elevated 5-hydroxymethylcytosine levels are a driver or a consequence of Parkinson’s disease.

Item Type: Article
Keywords: DNA, epigenetics, Parkinson's disease
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Biosciences
Identification Number: 10.1038/s41531-017-0007-3
Depositing User: Eprints, Support
Date Deposited: 02 Feb 2017 14:55
Last Modified: 14 Oct 2017 15:19
URI: http://eprints.nottingham.ac.uk/id/eprint/40271

Actions (Archive Staff Only)

Edit View Edit View