International criteria for acute kidney injury: advantages and remaining challenges

Selby, Nicholas M. and Fluck, Richard J. and Kolhe, Nitin V. and Taal, Maarten W. (2016) International criteria for acute kidney injury: advantages and remaining challenges. PLOS Medicine, 13 (9). e1002122/1-e1002122/8. ISSN 1549-1676

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Abstract

• Acute Kidney Injury (AKI) is defined using widely accepted international criteria that are based on changes in serum creatinine concentration and degree of oliguria.

• AKI, when defined in this way, has a strong association with poor patient outcomes, including high mortality rates and longer hospital admissions with increased resource utilisation and subsequent chronic kidney disease.

• The detection of AKI using current criteria can assist with AKI diagnosis and stratification of individual patient risk.

• The diagnosis of AKI requires clinical judgement to integrate the definition of AKI with the clinical situation, to determine underlying cause of AKI, and to take account of factors that may affect performance of current definitions.

Item Type: Article
Keywords: AKI, acute kidney injury; CKD, chronic kidney disease; GFR, glomerular filtration rate; KDIGO, Kidney Disease: Improving Global Outcomes; LMICs, low- and middle-income countries; RRT, renal replacement therapy
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Medical Sciences and Graduate Entry Medicine
Identification Number: https://doi.org/10.1371/journal.pmed.1002122
Depositing User: Eprints, Support
Date Deposited: 27 Jan 2017 12:32
Last Modified: 27 Jan 2017 13:31
URI: http://eprints.nottingham.ac.uk/id/eprint/40149

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