DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis

Glossop, John R. and Nixon, Nicola B. and Emes, Richard D. and Sim, Julius and Packman, Jon C. and Mattey, Derek L. and Farrell, William E. and Fryer, Anthony A. (2016) DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis. Epigenomics . ISSN 1750-192X

[img] PDF - Repository staff only until 25 November 2017. - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (1MB)

Abstract

Aim: A proof-of-concept study to explore whether DNA methylation at first diagnosis is associated with response to disease-modifying antirheumatic drugs (DMARDs) in patients with early rheumatoid arthritis (RA). Patients & methods: DNA methylation was quantified in T-lymphocytes from 46 treatment-naive patients using HumanMethylation450 BeadChips. Treatment response was determined in 6 months using the European League Against Rheumatism (EULAR) response criteria. Results: Initial filtering identified 21 cytosine-phosphate-guanines (CpGs) that were differentially methylated between responders and nonresponders. After conservative adjustment for multiple testing, six sites remained statistically significant, of which four showed high sensitivity and/or specificity (≥75%) for response to treatment. Moreover, methylation at two sites in combination was the strongest factor associated with response (80.0% sensitivity, 90.9% specificity, AUC 0.85). Conclusion: DNA methylation at diagnosis is associated with disease-modifying antirheumatic drug treatment response in early RA.

Item Type: Article
Additional Information: For full bibliographic citation, please refer to the version available at www.future-science.com
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: https://doi.org/10.2217/epi-2016-0042
Depositing User: Emes, Richard
Date Deposited: 27 Feb 2017 11:28
Last Modified: 27 Feb 2017 11:36
URI: http://eprints.nottingham.ac.uk/id/eprint/40090

Actions (Archive Staff Only)

Edit View Edit View