Acetylcholinesterase activity measurement and clinical features of delirium

Jackson, T.A. and Moorey, H.C. and Sheehan, B. and Maclullich, A.M.J. and Gladman, J.R.F. and Lord, J.M. (2017) Acetylcholinesterase activity measurement and clinical features of delirium. Dementia and Geriatric Cognitive Disorders, 43 (1-2). pp. 29-37. ISSN 1421-9824

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Abstract

Aims: Cholinergic deficiency is commonly implicated in the pathophysiology of delirium. We aimed to investigate the relationship between directly measured serum AChE activity and (1) clinical features of delirium and (2) outcomes, among older hospital patients with delirium.

Methods: Hospitalized patients with delirium were recruited and delirium motor subtype, severity and duration of delirium were measured. Serum AChE activity was measured using a colorimetric assay.

Results: The mean AChE activity for the whole sample was 2.46 μmol/μml/min (SD 1.75). Higher AChE activity was associated with increased likelihood of hypoactive delirium rather than the hyperactive or mixed subtype (OR 1.98, CI 1.10-3.59).

Conclusion: Higher AChE activity was associated with hypoactive delirium, but did not predict outcomes. Simple enhancement of cholinergic neurotransmission may not be sufficient to treat delirium

Item Type: Article
Keywords: Acetylcholinesterase activity, acetylcholine, delirium, cholinesterase inhibitors, aged, delirium motor subtype
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Rehabilitation and Ageing
Identification Number: 10.1159/000452832
Depositing User: Gladman, John
Date Deposited: 25 Jan 2017 15:33
Last Modified: 20 May 2017 18:42
URI: http://eprints.nottingham.ac.uk/id/eprint/40070

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