Nitric oxide sensing in plants is mediated by proteolytic control of Group VII ERF transcription factors

Gibbs, Daniel J. and Md Isa, Nurulhikma and Movahedi, Mahsa and Lozano-Juste, Jorge and Mendiondo, Guillermina M. and Berckhan, Sophie and Marín-de la Rosa, Nora and Vicente Conde, Jorge and Sousa Correia, Cristina and Pearce, Simon P. and Bassel, George W. and Hamali, Bulut and Talloji, Prabhavathi and Tomé, Daniel F.A. and Coego, Alberto and Beynon, Jim and Alabadí, David and Bachmair, Andreas and León, José and Gray, Julie E. and Theodoulou, Frederica L. and Holdsworth, Michael J. (2014) Nitric oxide sensing in plants is mediated by proteolytic control of Group VII ERF transcription factors. Molecular Cell, 53 (3). pp. 369-379. ISSN 1097-4164

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Abstract

Nitric oxide (NO) is an important signaling compound in prokaryotes and eukaryotes. In plants, NO regulates critical developmental transitions and stress responses. Here, we identify a mechanism for NO sensing that coordinates responses throughout development based on targeted degradation of plant-specific transcriptional regulators, the group VII ethylene response factors (ERFs). We show that the N-end rule pathway of targeted proteolysis targets these proteins for destruction in the presence of NO, and we establish them as critical regulators of diverse NO-regulated processes, including seed germination, stomatal closure, and hypocotyl elongation. Furthermore, we define the molecular mechanism for NO control of germination and crosstalk with abscisic acid (ABA) signaling through ERF-regulated expression of ABSCISIC ACID INSENSITIVE5 (ABI5). Our work demonstrates how NO sensing is integrated across multiple physiological processes by direct modulation of transcription factor stability and identifies group VII ERFs as central hubs for the perception of gaseous signals in plants.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Biosciences > Division of Plant and Crop Sciences
Identification Number: 10.1016/j.molcel.2013.12.020
Depositing User: Eprints, Support
Date Deposited: 24 Jan 2017 16:27
Last Modified: 14 Oct 2017 10:00
URI: http://eprints.nottingham.ac.uk/id/eprint/40042

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