Recent progress in translational research on neurovascular and neurodegenerative disorders

Demuth, Hans-Ulrich and Dijkhuizen, Rick M. and Farr, Tracy D. and Gelderblom, Mathias and Horsburgh, Karen and Iadecola, Constantino and Mcleod, Damian D. and Michalski, Dominik and Murphy, Tim H. and Orbe, Josuna and Otte, Willem M. and Petzold, Gabor C. and Plesnila, Nikolaus and Reiser, Georg and Reymann, Klaus G. and Rueger, Maria A. and Saur, Dorothee and Savitz, Sean I. and Schilling, Stephan and Spratt, Neil J. and Turner, Renée J. and Vemuganti, Raghu and Vivien, Denis and Yepes, Manuel and Zille, Marietta and Boltze, Johannes (2017) Recent progress in translational research on neurovascular and neurodegenerative disorders. Restorative Neurology and Neuroscience, 35 (1). pp. 87-103. ISSN 1878-3627

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Available under Licence Creative Commons Attribution Non-commercial.
Download (11MB) | Preview

Abstract

The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve the patient’s outcome. This has been paralleled by a swift increase in our understanding of pathomechanisms underlying many neurovascular diseases and most prevalent forms of dementia. Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience. Moreover, they may also pave the way for the renaissance of classical neuroprotective paradigms.

This review reports and summarizes some of the most interesting and promising recent achievements in neurovascular and dementia research. It highlights sessions from the 9th International Symposium on Neuroprotection and Neurorepair that have been discussed from April 19th to 22nd in Leipzig, Germany. To acknowledge the emerging culture of interdisciplinary collaboration and research, special emphasis is given on translational stories ranging from fundamental research on neurode- and -regeneration to late stage translational or early stage clinical investigations.

Item Type: Article
Keywords: Alzheimer’s disease, brain, cerebral ischemia, cerebral small vessel disease, dementia, experimental therapy, hemorrhage, in vivo imaging, neuroimmunology, neuroprotection, neurorepair, sex differences, stroke, translational research, vascular cognitive impairment
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number: https://doi.org/10.3233/RNN-160690
Depositing User: Eprints, Support
Date Deposited: 24 Jan 2017 09:15
Last Modified: 07 Feb 2017 06:28
URI: http://eprints.nottingham.ac.uk/id/eprint/40021

Actions (Archive Staff Only)

Edit View Edit View