Proteomic profiling of mitochondria: what does it tell us about the ageing brain?

Ingram, Thomas and Chakrabarti, Lisa (2016) Proteomic profiling of mitochondria: what does it tell us about the ageing brain? Aging, 8 (12). pp. 3161-3179. ISSN 1945-4589

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Abstract

Mitochondrial dysfunction is evident in numerous neurodegenerative and age-related disorders. It has also been linked to cellular ageing, however our current understanding of the mitochondrial changes that occur are unclear. Functional studies have made some progress reporting reduced respiration, dynamic structural modifications and loss of membrane potential, though there are conflicts within these findings. Proteomic analyses, together with functional studies, are required in order to profile the mitochondrial changes that occur with age and can contribute to unravelling the complexity of the ageing phenotype. The emergence of improved protein separation techniques, combined with mass spectrometry analyses has allowed the identification of age and cell-type specific mitochondrial changes in energy metabolism, antioxidants, fusion and fission machinery, chaperones, membrane proteins and biosynthesis pathways. Here, we identify and review recent data from the analyses of mitochondria from rodent brains. It is expected that knowledge gained from understanding age-related mitochondrial changes of the brain should lead to improved biomarkers of normal ageing and also age-related disease progression.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Biosciences > Division of Animal Sciences
Identification Number: https://doi.org/10.18632/aging.101131
Depositing User: Eprints, Support
Date Deposited: 23 Jan 2017 10:34
Last Modified: 24 Jan 2017 07:18
URI: http://eprints.nottingham.ac.uk/id/eprint/39994

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