Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities

Hens, Bart and Corsetti, Maura and Spiller, Robin C. and Marciani, Luca and Vanuytsel, Tim and Tack, Jan and Talattof, Arjang and Amidon, Gordon L. and Koziolek, Mirko and Weitschies, Werner and Wilson, Clive G. and Bennink, Roelof J. and Brouwers, Joachim and Augustijns, Patrick (2017) Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities. International Journal of Pharmaceutics, 519 (1-2). pp. 79-97. ISSN 1873-3476

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Abstract

Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables is critical for a continued progress in oral drug development. In this review, different methodologies (invasive versus non-invasive) to explore the impact of physiological variables on formulation behavior in the human GI tract are presented, revealing their strengths and limitations. The techniques mentioned allow for an improved understanding of the role of following GI variables: gastric emptying (magnetic resonance imaging (MRI), scintigraphy, acetaminophen absorption technique, ultrasonography, breath test, intraluminal sampling and telemetry), motility (MRI, small intestinal/colonic manometry and telemetry), GI volume changes (MRI and ultrasonography), temperature (telemetry) and intraluminal pH (intraluminal sampling and telemetry).

Item Type: Article
Keywords: Intestinal absorption, MRI, Scintigraphy, Manometry, Telemetry, Intraluminal profiling
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Nottingham Digestive Diseases Centre
Identification Number: 10.1016/j.ijpharm.2016.11.063
Depositing User: Marciani, Dr Luca
Date Deposited: 20 Jan 2017 08:52
Last Modified: 01 Dec 2017 10:17
URI: http://eprints.nottingham.ac.uk/id/eprint/39960

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