Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles

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Lester, Roy P., Bham, Travis, Bousfield, Thomas W., Lewis, William and Camp, Jason E. (2016) Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles. Journal of Organic Chemistry, 84 (24). pp. 12472-12477. ISSN 1520-6904

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Abstract

The reactivity of 2-trichloromethylbenzoxazoles towards various nucleophiles, under metal free or iron-catalyzed conditions, for the synthesis of substituted benzoxazoles is described. These methods allow for selective substitution at either the 2- or 2’- position of the benzoxazoles using the same starting materials / reagents. This approach allows for the controlled synthesis of a variety of key derivatives from a single 2-trichloromethylbenzoxazole starting material.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/836402
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number: https://doi.org/10.1021/acs.joc.6b02315
Depositing User: Bramwell, Roseanna
Date Deposited: 17 Jan 2017 13:42
Last Modified: 04 May 2020 18:27
URI: https://eprints.nottingham.ac.uk/id/eprint/39891

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