Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke

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Ahmed, Jewel, Dwyer, Dominic M., Farr, Tracy D., Harrison, David J., Dunnett, Stephen B. and Trueman, Rebecca C. (2016) Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke. Journal of Cerebral Blood Flow & Metabolism, 37 (3). pp. 755-761. ISSN 1559-7016

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Official URL: http://journals.sagepub.com/doi/10.1177/0271678X16684141

Abstract

The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimotor deficits up to 40 days after middle cerebral artery occlusion in rats. Impairments in drinking efficiency compared to controls, and a compensatory increase in the number of drinking clusters were observed. This highlights the utility of this easy to administer task in assessing subtle, long-term deficits, which could be likened to oral deficits in patients.

Item Type:	Article
RIS ID:	https://nottingham-repository.worktribe.com/output/773491
Keywords:	Animal models, behaviour (rodent), experimental, focal ischaemia, stroke
Schools/Departments:	University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number:	https://doi.org/10.1177/0271678X16684141
Depositing User:	Eprints, Support
Date Deposited:	11 Jan 2017 15:14
Last Modified:	04 May 2020 17:33
URI:	https://eprints.nottingham.ac.uk/id/eprint/39778

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