Surface-enhanced Raman spectroscopy study of 4-ATP on gold nanoparticles for basal cell carcinoma fingerprint detection

Quynh, Luu Manh and Nam, Nguyen Hoang and Kong, K. and Nhung, Nguyen Thi and Notingher, Ioan and Henini, M. and Luong, Nguyen Hoang (2016) Surface-enhanced Raman spectroscopy study of 4-ATP on gold nanoparticles for basal cell carcinoma fingerprint detection. Journal of Electronic Materials, 45 (5). pp. 2563-2568. ISSN 1543-186X

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Abstract

The surface-enhanced Raman signals of 4-aminothiophenol (4-ATP) attached to the surface of colloidal gold nanoparticles with size distribution of 2 to 5 nm were used as a labeling agent to detect basal cell carcinoma (BCC) of the skin. The enhanced Raman band at 1075 cm-1 corresponding to the C-S stretching vibration in 4-ATP was observed during attachment to the surface of the gold nanoparticles. The frequency and intensity of this band did not change when the colloids were conjugated with BerEP4 antibody, which specifically binds to BCC. We show the feasibility of imaging BCC by surface-enhanced Raman spectroscopy, scanning the 1075 cm-1 band to detect the distribution of 4ATP-coated gold nanoparticles attached to skin tissue ex vivo.

Item Type: Article
Additional Information: (c) 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.
Keywords: Skin cancer, Basal cell carcinoma, Surface-enhanced Raman scattering, Gold nanoparticles
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Physics and Astronomy
Identification Number: https://doi.org/10.1007/s11664-016-4421-9
Depositing User: Henini, Mohamed
Date Deposited: 10 Jan 2017 13:40
Last Modified: 10 Jan 2017 22:30
URI: http://eprints.nottingham.ac.uk/id/eprint/39516

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