Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury

Osna, Natalie and Carter, Wayne G. and Ganesan, Murali and Kirpich, Irina A. and McClain, Criag J. and Petersen, Dennis R. and Shearn, Colin T. and Tomasi, Maria L. and Kharbanda, Kusum (2016) Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury. World Journal of Gastroenterology, 22 (27). pp. 6192-6200. ISSN 2219-2840

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Abstract

It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cellular hemostasis. Alcohol exposure significantly alters several of these post-translational modifications leading to impairments of many essential physiological processes. Here, we present new insights into novel modifications following ethanol exposure and their role in the initiation and progression of liver injury. This critical review condenses the proceedings of a symposium at the European Society for the Biomedical Research on Alcoholism Meeting held September 12-15, 2015, in Valencia, Spain.

Item Type: Article
Keywords: Alcohol; Acetylation; Liver; Carbonylation methylation; Dysfunction; Methylation; Glycosylation; Phosphorylation; Ubiquitination; Sumoylation; Betaine; Post-translational protein modification
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
Identification Number: https://doi.org/10.3748/wjg.v22.i27.6192
Depositing User: Eprints, Support
Date Deposited: 05 Dec 2016 14:29
Last Modified: 06 Dec 2016 23:31
URI: http://eprints.nottingham.ac.uk/id/eprint/39167

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