Risk of venous thromboembolism in children after general surgery

Humes, David J., Nordenskjöld, Agneta, Walker, Alex J., West, Joe and Ludvigsson, Jonas F. (2015) Risk of venous thromboembolism in children after general surgery. Journal of Pediatric Surgery, 50 (11). pp. 1870-1873. ISSN 1531-5037

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Background/purpose: The purpose of the study was to determine absolute and relative rates of venous thromboembolism (VTE) following general surgical procedures in children compared to the general population.

Methods: We analyzed data from all patients under the age of 18 years in the Clinical Practice Research Datalink, linked to Hospital Episode Statistics from England (2001–2011) undergoing a general surgical procedure and population controls. Crude rates of VTE and adjusted hazard ratios were calculated using Cox regression. Results We identified 15,637 children who had a surgical procedure with 161,594 controls. Six children undergoing surgery had a VTE diagnosed in the year after compared to five children in the population cohort. The overall rate of VTE following surgery was 0.4 per 1000 person years (pyrs) (95% confidence interval [CI] 0.15–0.88) compared to 0.04 per 1000 pyrs (95% CI 0.02–0.09) in the population cohort. This represented a 9 fold increase in risk compared to the population cohort (adjusted hazard ratio [HR] 8.80; 95% CI 2.59–29.94).

Conclusions Children are at increased risk for VTE following general surgical procedures compared to the general population however the absolute risk is small and given this the benefits of thromboprophylaxis need to be balanced against the risk of complications following its use.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/750938
Keywords: Deep vein thrombosis Pulmonary embolus General surgery
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health
Identification Number: https://doi.org/10.1016/j.jpedsurg.2015.05.010
Depositing User: Claringburn, Tara
Date Deposited: 02 Dec 2016 13:47
Last Modified: 04 May 2020 17:07
URI: https://eprints.nottingham.ac.uk/id/eprint/39135

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