Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke

Ahmed, Jewel and Dwyer, Dominic E. and Farr, Tracy D. and Harrison, David J. and Dunnett, Stephen B. and Trueman, Rebecca C. (2017) Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke. Journal of Cerebral Blood Flow & Metabolism . ISSN 1559-7016

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Abstract

The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimotor deficits up to 40 days after middle cerebral artery occlusion in rats. Impairments in drinking efficiency compared to controls, and a compensatory increase in the number of drinking clusters were observed. This highlights the utility of this easy to administer task in assessing subtle, long-term deficits, which could be likened to oral deficits in patients.

Item Type: Article
Keywords: Animal Models; Behavior (rodent); Experimental; Focal Ischemia; Stroke
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number: 10.1177/0271678X16684141
Depositing User: Trueman, Rebecca
Date Deposited: 18 Nov 2016 09:29
Last Modified: 09 Jul 2017 20:52
URI: http://eprints.nottingham.ac.uk/id/eprint/38803

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