The pattern of underlying cause of death in patients with inflammatory bowel disease in England: a record linkage study

Chu, Thomas P.C. and Moran, Gordon W. and Card, Timothy R. (2016) The pattern of underlying cause of death in patients with inflammatory bowel disease in England: a record linkage study. Journal of Crohn's and Colitis . pp. 1-8. ISSN 1876-4479

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Abstract

Background and Aims: Numerous studies have established that mortality risk in IBD patients is higher than the general population, but the causes of death have seldom been examined. We aimed to describe causes of death in IBD.

Methods: A matched cohort study using UK general practice data from Clinical Practice Research Datalink linked to death registration records. We described the distribution of causes of death among IBD patients by age at death and time since IBD diagnosis. We estimated age-specific mortality rates and hazard ratios of death in multivariable Cox proportional hazards models.

Results: 20,293 IBD patients were matched to 83,261 non-IBD patients. The mortality rate was 40% higher in IBD patients (2005 deaths) than in non-IBD patients (6024 deaths) (adjusted overall hazard ratio = 1.4, 95% CI = 1.4—1.5), with greater risk of death in Crohn’s disease (hazard ratio = 1.6, 1.5—1.7) than in ulcerative colitis (1.3, 1.3—1.4). Causes attributable to IBD constituted 3.7% of all deaths in ulcerative colitis and 8.3% in Crohn’s disease. Among IBD patients, death was less likely to be due to circulatory, respiratory or neoplastic diseases than non-IBD patients. In both IBD and non-IBD patients all these causes became more clinically important with advancing age, with the commonest neoplastic cause of death being lung cancer, rather than gastrointestinal cancers.

Conclusion: IBD patients have an additional risk of death. Most IBD patients die of circulatory or respiratory causes, and the contribution to mortality from long-term complications of IBD are clinically less important.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Chrohn's and Colitis following peer review. The version of record homas P. C. Chu, Gordon W. Moran, Timothy R. Card; The Pattern of Underlying Cause of Death in Patients with Inflammatory Bowel Disease in England: A Record Linkage Study. J Crohns Colitis 2016 jjw192. doi: 10.1093/ecco-jcc/jjw192 is available online at: https://academic.oup.com/ecco-jcc/article-lookup/doi/10.1093/ecco-jcc/jjw192
Keywords: inflammatory bowel disease, epidemiology, mortality, cause of death
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
Identification Number: https://doi.org/10.1093/ecco-jcc/jjw192
Depositing User: Claringburn, Tara
Date Deposited: 11 Nov 2016 11:58
Last Modified: 09 Feb 2017 18:59
URI: http://eprints.nottingham.ac.uk/id/eprint/38650

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