Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni)

de Brot, Simone and Sydler, Titus and Nufer, Lisbeth and Ruetten, Maja (2015) Histologic, immunohistochemical, and electron microscopic characterization of a malignant iridophoroma in a dwarf bearded dragon (Pogona henrylawsoni). Journal of Zoo and Wildlife Medicine, 46 (3). pp. 583-587. ISSN 1937-2825

[img] PDF - Repository staff only - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (445kB)

Abstract

A dwarf bearded dragon (Pogona henrylawsoni) was presented with a whitish subcutaneous mandibular mass and multiple nodules in the oral mucosa, heart, liver, kidney, intestine and visceral fat. Histologically, the tumor consisted of densely packed spindle-shaped cells with brownish intracytoplasmic pigment that exhibited white-bluish birefringence with polarized light. Immunohistochemical staining was negative for S-100 and weakly positive with Melan A. Negative contrast electron microscopic examination revealed cytoplasmic irregular, oblong empty spaces, laminated and often arranged into short stacks, compatible with reflecting platelet profiles typically seen in iridophores. However, in unstained ultrathin sections, electron dense crystalline material was present which filled the empty spaces described for stained sections before. Based on histology, immunohistochemistry and biological behavior, a malignant iridophoroma was diagnosed. To the authors’ knowledge, iridophoromas in lizards have not been characterized before by using electronic microscopy. Moreover, this is the first description of an iridophoroma in a dwarf bearded dragon.

Item Type: Article
Keywords: Chromatophoroma, Dwarf bearded dragon, Electron microscopy, Iridophoroma, Pogona henrylawsoni
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: 10.1638/2013-0113.1
Depositing User: de Brot, Dr Simone
Date Deposited: 24 Feb 2017 09:47
Last Modified: 14 Oct 2017 06:59
URI: http://eprints.nottingham.ac.uk/id/eprint/38062

Actions (Archive Staff Only)

Edit View Edit View