The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

Pawson, Adam J. and Sharman, Joanna L. and Benson, Helen E. and Faccenda, Elena and Alexander, Stephen P.H. and Buneman, O. Peter and Davenport, Anthony P. and McGrath, John C. and Peters, John A. and Southan, Christopher and Spedding, Michael and Yu, Wenyuan and Harmar, Anthony J. (2014) The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucleic Acids Research, 42 (D1). D1098-D1106. ISSN 1362-4962

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Abstract

The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY (http://www.guidetopharmacology.org) is a new open access resource providing pharmacological, chemical, genetic, functional and pathophysiological data on the targets of approved and experimental drugs. Created under the auspices of the IUPHAR and the BPS, the portal provides concise, peer-reviewed overviews of the key properties of a wide range of established and potential drug targets, with in-depth information for a subset of important targets. The resource is the result of curation and integration of data from the IUPHAR Database (IUPHAR-DB) and the published BPS 'Guide to Receptors and Channels' (GRAC) compendium. The data are derived from a global network of expert contributors, and the information is extensively linked to relevant databases, including ChEMBL, DrugBank, Ensembl, PubChem, UniProt and PubMed. Each of the approximately 6000 small molecule and peptide ligands is annotated with manually curated 2D chemical structures or amino acid sequences, nomenclature and database links. Future expansion of the resource will complete the coverage of all the targets of currently approved drugs and future candidate targets, alongside educational resources to guide scientists and students in pharmacological principles and techniques

Item Type: Article
Additional Information: © The Author(s) 2013. Published by Oxford University Press.
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences > School of Biomedical Sciences
Identification Number: https://doi.org/10.1093/nar/gkt1143
Depositing User: Alexander, Stephen
Date Deposited: 31 Oct 2016 09:09
Last Modified: 31 Oct 2016 09:09
URI: http://eprints.nottingham.ac.uk/id/eprint/38017

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