Hereditary nephropathy in an English Cocker Spaniel

de Brot, Simone and Adamany, J. and Baiker, K. and Allegrucci, Cinzia and Polledo, L. and Grau-Roma, Llorenc (2015) Hereditary nephropathy in an English Cocker Spaniel. Journal of the American Veterinary Medical Association . ISSN 1943-569X (In Press)

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Abstract

A thirteen-month-old male neutered orange roan English Cocker Spaniel dog was euthanized due to a prolonged history of lethargy, weight loss, severe azotemia and marked proteinuria, which was suggestive of chronic renal failure. At necropsy, both kidneys were pale tan and presented with a diffusely rough and granular appearing surface. Histologically, both kidneys showed severe, generalized, segmental to global, chronic membranoproliferative glomerulonephritis with glomerulosclerosis and proteinuria. DNA was extracted from hair follicles collected at necropsy, and a PCR amplifying exon 3 of gene COL4A4 was performed. The PCR showed that this dog had a homozygous mutation at the position 115 of the gene COL4A4, indicating that this dog suffered from hereditary nephropathy.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Depositing User: Grau Roma, Llorenc
Date Deposited: 26 Oct 2016 10:52
Last Modified: 26 Oct 2016 10:59
URI: http://eprints.nottingham.ac.uk/id/eprint/37944

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