3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles

Khaled, Shaban A. and Burley, Jonathan C. and Alexander, Morgan R. and Yang, Jing and Roberts, Clive J. (2015) 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. Journal of Controlled Release, 217 . pp. 308-314. ISSN 1873-4995

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Abstract

We have used three dimensional (3D) extrusion printing to manufacture a multi-active solid dosage form or so called polypill. This contains five compartmentalised drugs with two independently controlled and well-defined release profiles. This polypill demonstrates that complex medication regimes can be combined in a single personalised tablet. This could potentially improve adherence for those patients currently taking many separate tablets and also allow ready tailoring of a particular drug combination/drug release for the needs of an individual. The polypill here represents a cardiovascular treatment regime with the incorporation of an immediate release compartment with aspirin and hydrochlorothiazide and three sustained release compartments containing pravastatin, atenolol, and ramipril. X-ray powder diffraction (XRPD) and Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) were used to assess drug-excipient interaction. The printed polypills were evaluated for drug release using USP dissolution testing. We found that the polypill showed the intended immediate and sustained release profiles based upon the active/excipient ratio used.

Item Type: Article
Keywords: 3D printing; Polypill; Sustained release; Immediate release; Personalised medicine
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Pharmacy
Identification Number: https://doi.org/10.1016/j.jconrel.2015.09.028
Depositing User: Roberts, Prof Clive J
Date Deposited: 20 Oct 2016 14:48
Last Modified: 21 Oct 2016 15:33
URI: http://eprints.nottingham.ac.uk/id/eprint/37750

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