Glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial

Forrester, Doug L. and Knox, Alan J. and Smyth, Alan R. and Barr, Helen L. and Simms, Rebecca and Pacey, Sarah J. and Pavord, Ian D. and Honeybourne, David and Dewar, Jane and Clayton, Andy and Fogarty, Andrew W. (2015) Glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial. Pediatric Pulmonology, 51 (3). pp. 253-257. ISSN 1099-0496

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Abstract

Rationale: Pulmonary infection and malnutrition in cystic fibrosis are associated with decreased survival. Glutamine has a possible anti-microbial effect, with a specific impact against Pseudomonas aeruginosa. We aimed to test the hypothesis that oral glutamine supplementation (21 g/day) for 8 weeks in adults with cystic fibrosis would decrease pulmonary inflammation and improve clinical status.

Methods: The study design was a randomized double-blind placebo-controlled study design with an iso-nitrogenous placebo. The primary analysis was intention to treat, and the primary outcome was change in induced sputum neutrophils.

Results: Thirty-nine individuals were recruited and thirty-six completed the study. Glutamine supplementation had no impact on any of the outcome measures in the intention-to-treat analysis. In the per protocol analysis, glutamine supplementation was associated with an increase in induced sputum neutrophils (P = 0.046), total cells (P = 0.03), and in Pseudomonas isolation agar colony forming units (P = 0.04) compared to placebo.

Conclusions: There was no effect of glutamine supplementation on markers of pulmonary inflammation in the intention-to-treat analysis.

Item Type: Article
Additional Information: "This is the peer reviewed version of the following article: Doug L. Forrester, Alan J. Knox, Alan R. Smyth, Helen L. Barr, Rebecca Simms, Sarah J. Pacey, Ian D. Pavord, David Honeybourne, Jane Dewar, Andy Clayton and Andrew W. Fogarty. (2016) Pediatric pulmonary 51 (3): 253-257, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/ppul.23370/full This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
Keywords: glutamine cystic fibrosis infection nutrition
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Child Health, Obstetrics and Gynaecology
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Respiratory Medicine
Identification Number: https://doi.org/10.1002/ppul.23370
Depositing User: Claringburn, Tara
Date Deposited: 20 Oct 2016 10:02
Last Modified: 20 Jan 2017 16:12
URI: http://eprints.nottingham.ac.uk/id/eprint/37727

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