Maternal body weight and gestational diabetes differentially influence placental and pregnancy outcomes

Martino, J. and Sebert, S. and Segura, M.T. and García-Valdés, L. and Florido, J. and Padilla, M.C. and Marcos, A. and Rueda, R. and McArdle, H.J. and Budge, H. and Symonds, Michael E. and Campoy, C. (2015) Maternal body weight and gestational diabetes differentially influence placental and pregnancy outcomes. Journal of Clinical Endocrinology and Metabolism, 101 (1). pp. 59-68. ISSN 1945-7197

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (797kB) | Preview

Abstract

Context:

Maternal obesity and gestational diabetes mellitus (GDM) can both contribute to adverse neonatal outcomes. The extent to which this may be mediated by differences in placental metabolism and nutrient transport remains to be determined.

Objective:

Our objective was to examine whether raised maternal body mass index (BMI) and/or GDM contributed to a resetting of the expression of genes within the placenta that are involved in energy sensing, oxidative stress, inflammation, and metabolic pathways.

Methods:

Pregnant women from Spain were recruited as part of the “Study of Maternal Nutrition and Genetics on the Foetal Adiposity Programming” survey at the first antenatal visit (12–20 weeks of gestation) and stratified according to prepregnancy BMI and the incidence of GDM. At delivery, placenta and cord blood were sampled and newborn anthropometry measured.

Results:

Obese women with GDM had higher estimated fetal weight at 34 gestational weeks and a greater risk of preterm deliveries and cesarean section. Birth weight was unaffected by BMI or GDM; however, women who were obese with normal glucose tolerance had increased placental weight and higher plasma glucose and leptin at term. Gene expression for markers of placental energy sensing and oxidative stress, were primarily affected by maternal obesity as mTOR was reduced, whereas SIRT-1 and UCP2 were both upregulated. In placenta from obese women with GDM, gene expression for AMPK was also reduced, whereas the downstream regulator of mTOR, p70S6KB1 was raised.

Conclusions:

Placental gene expression is sensitive to both maternal obesity and GDM which both impact on energy sensing and could modulate the effect of either raised maternal BMI or GDM on birth weight.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Child Health, Obstetrics and Gynaecology
Identification Number: 10.1210/jc.2015-2590
Depositing User: Eprints, Support
Date Deposited: 19 Oct 2016 08:16
Last Modified: 01 Apr 2017 08:46
URI: http://eprints.nottingham.ac.uk/id/eprint/37708

Actions (Archive Staff Only)

Edit View Edit View