Pereira, Bernard and Chin, Suet-Feung and Rueda, Oscar M. and Vollan, Hans-Kristian Moen and Provenzano, Elena and Bardwell, Helen A. and Pugh, Michelle and Jones, Linda and Russell, Roslin and Sammut, Stephen-John and Tsui, Dana W.Y. and Liu, Bin and Dawson, Sarah-Jane and Abraham, Jean and Northen, Helen and Peden, John F. and Mukherjee, Abhik and Turashvili, Gulisa and Green, Andrew R. and McKinney, Steve and Oloumi, Arusha and Shah, Sohrab and Rosenfeld, Nitzan and Murphy, Leigh and Bentley, David R. and Ellis, Ian O. and Purushotham, Arnie and Pinder, Sarah E. and Børresen-Dale, Anne-Lise and Earl, Helena M. and Pharoah, Paul D. and Ross, Mark T. and Aparicio, Samuel and Caldas, Carlos
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.
Nature Communications, 7
The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating the disease. In this study, we sequence 173 genes in 2,433 primary breast tumours that have copy number aberration (CNA), gene expression and long-term clinical follow-up data. We identify 40 mutation-driver (Mut-driver) genes, and determine associations between mutations, driver CNA profiles, clinical-pathological parameters and survival. We assess the clonal states of Mut-driver mutations, and estimate levels of intra-tumour heterogeneity using mutant-allele fractions. Associations between PIK3CA mutations and reduced survival are identified in three subgroups of ER-positive cancer (defined by amplification of 17q23, 11q13–14 or 8q24). High levels of intra-tumour heterogeneity are in general associated with a worse outcome, but highly aggressive tumours with 11q13–14 amplification have low levels of intra-tumour heterogeneity. These results emphasize the importance of genome-based stratification of breast cancer, and have important implications for designing therapeutic strategies.
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