Developing Mn-doped lead sulfide quantum dots for MRI labels
Turyanska, Lyudmila and Moro, Fabrizio and Patanè, Amalia and Barr, James and Köckenberger, Walter and Taylor, Alexander and Faas, Henryk and Fowler, Maxine J. and Wigmore, Peter and Trueman, Rebecca C. and Williams, Huw Edward Llewelyn and Thomas, Neil R. (2016) Developing Mn-doped lead sulfide quantum dots for MRI labels. Journal of Materials Chemistry B . ISSN 2050-750X (In Press)
Magnetic interactions of Mn2+ions in lead sulfide (PbS) nanocrystals with protons in water are probed by NMR and MRI. A thin layer of capping molecules enables free solvent diffusion to the nanocrystal surface resulting in a decrease of proton relaxation times. Magnetic resonance imaging of neuronal cell pellets exposed to (PbMn)S at non-toxic concentrations demonstrates their prospects as MRI-labels.
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