Gelation properties of self-assembling N-acyl modified cytidine derivatives

Skilling, Kathryn J. and Ndungu, A. and Kellam, Barrie and Ashford, M. and Bradshaw, Tracey D. and Marlow, Maria (2014) Gelation properties of self-assembling N-acyl modified cytidine derivatives. Journal of Materials Chemistry B, 2 (47). pp. 8412-8417. ISSN 2050-750X

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In this study we report the synthesis of new cytidine derived gelators possessing acyl chains of different lengths. These low molecular weight gelators were shown to form self-supporting gels at 0.5 % (w/v) in binary systems of aqueous miscible polar organic solvent and water. The representative gels were studied using rheology and their fibrillar structure confirmed by TEM imaging and FTIR. We further demonstrated the use of these gels as potential drug delivery platforms by monitoring release characteristics of both high and low molecular weight fluorescently labelled tracers.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Science > School of Pharmacy
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Depositing User: Eprints, Support
Date Deposited: 04 Oct 2016 08:52
Last Modified: 16 Oct 2016 00:56

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