Developing a self-healing supramolecular nucleoside hydrogel

Skilling, Kathryn J. and Kellam, Barrie and Ashford, M. and Bradshaw, Tracey D. and Marlow, Maria (2016) Developing a self-healing supramolecular nucleoside hydrogel. Soft Matter . ISSN 1744-6848

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Abstract

Low molecular weight gelator hydrogels provide a viable alternative to traditional polymer based drug delivery platforms, owing to their tunable stability and in most cases inherent biocompatibility. Here we report the first self-healing nucleoside hydrogel using N4-octanoyl-2′-deoxycytidine (0.5% w/v) for drug delivery. The hydrogel's cross-linked nanofibrillar structure, was characterised using oscillatory rheology and confirmed using SEM and TEM imaging. The potential of this gel for drug delivery was explored in vitro using fluorescently labelled tracers. Cell viability assays were conducted using pancreatic cell lines which tolerated the gels well; whilst no adverse effects on the viability or proliferation of cells were observed for fibroblast cell lines.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Science > School of Pharmacy
Identification Number: https://doi.org/10.1039/C6SM01779G
Depositing User: Eprints, Support
Date Deposited: 04 Oct 2016 08:36
Last Modified: 16 Oct 2016 03:47
URI: http://eprints.nottingham.ac.uk/id/eprint/37330

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