High PEEP in ARDS: quantitative evaluation between improved oxygenation and decreased oxygen delivery
Chikhani, M. and Das, A. and Haque, M. and Wang, W. and Bates, D.G. and Hardman, J.G. (2016) High PEEP in ARDS: quantitative evaluation between improved oxygenation and decreased oxygen delivery. British Journal of Anaesthesia . ISSN 1471-6771 (In Press)
Background: Positive end-expiratory pressure (PEEP) is widely used to improve oxygenation and prevent alveolar collapse in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). While PEEP predictably improves arterial oxygenation, high PEEP strategies have demonstrated equivocal improvements in ARDS mortality. The effect of PEEP on tissue oxygen delivery is poorly understood and is difficult to quantify or investigate in the clinical environment.
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