Dichgans, Martin and Wardlaw, Joanna and Smith, Eric and Zietemann, Vera and Seshadri, Sudha and Sachdev, Perminder and Biessels, Geert Jan and Fazekas, Franz and Benavente, Oscar and Pantoni, Leonardo and De Leeuw, Frank-Erik and Norrving, Bo and Matthews, Paul and Chen, Christopher and Mok, Vincent and Düring, Marco and Whiteley, Will and Shuler, Kirsten and Alonso, Alvaro and Black, Sandra E. and Brayne, Carol and Chabriat, Hugues and Cordonnier, Charlotte and Doubal, Fergus and Duzel, Emrah and Ewers, Michael and Frayne, Richard and Hachinski, Vladimir and Ikram, Mohammad Arfan and Jessen, Frank and Jouvent, Eric and Linn, Jennifer and O'Brien, John and van Oostenbrugge, Robert and Malik, Rainer and Mazoyer, Bernard and Schmidt, Reinhold and Sposato, Luciano A. and Stephan, Blossom and Swartz, Richard H. and Vernooij, Meike and Viswanathan, Anand and Werring, David and Abe, Koji and Allan, Louise and Arba, Francesco and Diener, H.-C. and Davis, S. and Hankey, G. and Lees, K.R. and Ovbiagele, B. and Weir, C. and Bae, Hee-Joon and Bath, Philip M.W. and Bordet, Regis and Breteler, Monique and Choi, Seong and Deary, Ian and DeCarli, Charles and Ebmeier, Klaus and Feng, Lei and Greenberg, Steven M. and Ihara, Masafumi and Kalaria, Rajesh and Kim, SanYun and Lim, Jae-Sung and Lindley, Richard I. and Mead, Gillian and Murray, Alison and Quinn, Terry and Ritchie, Craig and Sacco, Ralph and Al-Shahi Salman, Rustam and Sprigg, Nikola and Sudlow, Cathie and Thomas, Alan and van Boxtel, Martin and van der Grond, Jeroen and van der Lugt, Aad and Yang, Yuan-Han
METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: an initiative of the Joint Programme for Neurodegenerative Disease Research.
Alzheimer's & Dementia
Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer's disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel disease, is hampered by imprecise data, including the incidence and prevalence of symptomatic and clinically “silent” cerebrovascular disease, long-term outcomes (cognitive, stroke, or functional), and risk factors. New large collaborative studies with long follow-up are expensive and time consuming, yet substantial data to advance the field are available. In an initiative funded by the Joint Programme for Neurodegenerative Disease Research, 55 international experts surveyed and assessed available data, starting with European cohorts, to promote data sharing to advance understanding of how vascular disease affects brain structure and function, optimize methods for cerebrovascular disease in neurodegeneration research, and focus future research on gaps in knowledge. Here, we summarize the results and recommendations from this initiative. We identified data from over 90 studies, including over 660,000 participants, many being additional to neurodegeneration data initiatives. The enthusiastic response means that cohorts from North America, Australasia, and the Asia Pacific Region are included, creating a truly global, collaborative, data sharing platform, linked to major national dementia initiatives. Furthermore, the revised World Health Organization International Classification of Diseases version 11 should facilitate recognition of vascular-related brain damage by creating one category for all cerebrovascular disease presentations and thus accelerate identification of targets for dementia prevention.
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