Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease

Selvarajah, Senthooran and Todd, Ian and Tighe, Patrick J. and John, Michelle and Bolton, Charlotte E. and Harrison, Timothy and Fairclough, Lucy C. (2016) Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease. Mediators of Inflammation, 2016 . p. 3604842. ISSN 1466-1861

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Abstract

Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multiple cytokines in small volumes of serum. Fourteen cytokines were measured in serum from never-smokers, ex-smokers, current smokers, and COPD patients (GOLD stages 1–3). Certain individual circulating cytokines (particularly TNFa and IL-1b) were significantly elevated in concentration in the serum of particular COPD patients (and some current/ex-smokers without COPD) and may serve as markers of particularly significant systemic inflammation. However, numerous circulating cytokines were raised such that their combined, but not individual, elevation was significantly associated with severity of disease, and these may be further indicators of, and contributors to, the systemic inflammatory manifestations of COPD. The coelevation of numerous circulating cytokines in COPD is consistent with the insidious development, chronic nature, and systemic comorbidities of the disease.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Division of Respiratory Medicine
University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number: https://doi.org/10.1155/2016/3604842
Depositing User: Eprints, Support
Date Deposited: 23 Sep 2016 12:25
Last Modified: 23 Sep 2016 12:27
URI: http://eprints.nottingham.ac.uk/id/eprint/37080

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