Modulation of the turkey β1-adrenergic receptor by membrane rafts: insight from molecular dynamics

Ghumman, Afshan and Robinson, David (2016) Modulation of the turkey β1-adrenergic receptor by membrane rafts: insight from molecular dynamics. ChemistrySelect, 1 (14). pp. 4274-4276. ISSN 2365-6549

[img] PDF - Repository staff only until 8 September 2017. - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (442kB)

Abstract

G-protein coupled receptors are targets for ~70% of drugs. These receptors are responsible for signal transduction within a cell membrane (and further into the cell) and disruption to this signaling cascade is responsible for several non-infectious diseases. Membrane rafts exhibit significantly altered properties in comparison to fluid bilayers and as such may regulate certain GPCR’s, or be responsible for errors in signaling. Using molecular dynamics, we have investigated the conformations of the turkey β1-adrenergic receptor with and without an agonist in sphingolipid and cholesterol rich bilayers, typical of raft compositions, and compared these to cholesterol-poor bilayers. We find that the raft-like lipid bilayers are responsible for significantly altering the conformation of the receptor, even when an agonist is present.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: A. Ghumman, D. Robinson, Modulation of the turkey β1-adrenergic receptor by membrane rafts : insight from molecular dynamics. ChemistrySelect 2016, v. 1, no. 14, p. 4274–4276 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/slct.201600849/abstract;jsessionid=E2A11EE4B26662EF19BAFB412FC1E462.f01t03. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Schools/Departments: University of Nottingham UK Campus > Faculty of Science > School of Chemistry
Identification Number: https://doi.org/10.1002/slct.20160084
Depositing User: Bramwell, Roseanna
Date Deposited: 13 Sep 2016 10:20
Last Modified: 17 Sep 2016 15:12
URI: http://eprints.nottingham.ac.uk/id/eprint/36524

Actions (Archive Staff Only)

Edit View Edit View