A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA)
Hodgson, David and Anderson, John and Reynolds, Catherine and Meakin, Garry and Bailey, Helen and Pavord, Ian and Shaw, Dominick E. and Harrison, Timothy W. (2015) A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA). Thorax, 70 (6). pp. 559-565. ISSN 1468-3296
Official URL: http://thorax.bmj.com/content/70/6/559
Background: Some patients with refractory asthma have evidence of uncontrolled eosinophilic inflammation in the distal airways. While traditional formulations of inhaled steroids settle predominantly in the large airways, newer formulations with an extra-fine particle size have a more peripheral pattern of deposition. Specifically treating distal airway inflammation may improve asthma control.
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