Robust anti-nociceptive effects of MAG lipase inhibition in a model of osteoarthritis pain
Burston, James J. and Mapp, Paul I. and Sarmad, Sarir and Barrett, David A. and Niphakis, Micah J. and Cravatt, Benjamin F. and Walsh, David A. and Chapman, Victoria (2016) Robust anti-nociceptive effects of MAG lipase inhibition in a model of osteoarthritis pain. British Journal of Pharmacology, 173 (21). pp. 3134-3144. ISSN 1476-5381
BACKGROUND AND PURPOSE: Chronic pain is often a symptom of knee osteoarthritis (OA) for which current analgesics are either inadequate, or are associated with serious side effects. The endocannabinoid system may offer alternative targets for pain-relief. We evaluated the effects of a potent and selective MAG lipase inhibitor (MJN110) on OA pain behaviour, spinal mechanisms of action and joint histopathology in the rat.
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