The spatiotemporal order of signaling events unveils the logic of development signaling
Zhu, Hao and Owen, Markus R. and Mao, Yanlan (2016) The spatiotemporal order of signaling events unveils the logic of development signaling. Bioinformatics, 32 (15). pp. 2313-2320.
Motivation: Animals from worms and insects to birds and mammals show distinct body plans; however, the embryonic development of diverse body plans with tissues and organs within is controlled by a surprisingly few signaling pathways. It is well recognized that combinatorial use of and dynamic interactions among signaling pathways follow specific logic to control complex and accurate developmental signaling and patterning, but it remains elusive what such logic is, or even, what it looks like.
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