Screening for celiac disease in the general population and in high-risk groups

Ludvigsson, Jonas F. and Card, Timothy R. and Kaukinen, Katri and Bai, Julio and Zingone, Fabiana and Sanders, David S. and Murray, Joseph A. (2014) Screening for celiac disease in the general population and in high-risk groups. United European Gastroenterology Journal, 3 (2). pp. 106-120. ISSN 2050-6414

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Abstract

BACKGROUND: Celiac disease (CD) occurs in approximately 1% of the Western population. It is a lifelong disorder that is associated with impaired quality of life (QOL) and an excessive risk of comorbidity and death.

OBJECTIVES: To review the literature on screening for CD in relation to the current World Health Organization (WHO) criteria for mass screening.

METHODS: We performed a PubMed search to identify indexed papers on CD screening with a publication date from 1900 until 1 June 2014. When we deemed an abstract relevant, we read the corresponding paper in detail.

RESULTS: CD fulfills several WHO criteria for mass screening (high prevalence, available treatment and difficult clinical detection), but it has not yet been established that treatment of asymptomatic CD may reduce the excessive risk of severe complications, leading to higher QOL nor that it is cost-effective.

CONCLUSIONS: Current evidence is not sufficient to support mass screening for CD, but active case-finding may be appropriate, as we recognize that most patients with CD will still be missed by this strategy. Although proof of benefit is still lacking, screening for CD may be appropriate in high-risk groups.

Item Type: Article
Keywords: Celiac disease, gluten, gluten-free diet, review, screening, prevention, risk, quality of life, World Health Organization
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health
Identification Number: https://doi.org/10.1177/2050640614561668
Related URLs:
URLURL Type
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406899/UNSPECIFIED
Depositing User: Claringburn, Tara
Date Deposited: 17 Aug 2016 08:05
Last Modified: 19 Sep 2016 16:14
URI: http://eprints.nottingham.ac.uk/id/eprint/35870

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