Investigating the microrheology of the vitreous humor using an optically trapped local probe

Watts, Fiona and Tan, Lay Ean and Wilson, Clive G. and Girkin, John M. and Tassieri, Manlio and Wright, Amanda J. (2013) Investigating the microrheology of the vitreous humor using an optically trapped local probe. Journal of Optics, 16 (1). ISSN 2040-8986

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Abstract

We demonstrate that an optically trapped silica bead can be used as a local probe to measure the micro-rheology of the vitreous humor. The Brownian motion of the bead was observed using a fast camera and the micro-rheology determined by analysis of the time-dependent mean-square displacement of the bead. We observed regions of the vitreous that showed different degrees of viscoelasticity, along with the homogeneous and inhomogeneous nature of different regions. The motivation behind this study is to understand the vitreous structure, in particular changes due to aging, allowing more confident prediction of pharmaceutical drug behavior and delivery within the vitreous humor.

Item Type: Article
Keywords: optical trapping, micro-rheology, vitreous humor
Schools/Departments: University of Nottingham UK Campus > Faculty of Engineering
University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number: https://doi.org/10.1088/2040-8978/16/1/015301
Depositing User: Eprints, Support
Date Deposited: 10 Aug 2016 13:02
Last Modified: 25 Sep 2016 20:32
URI: http://eprints.nottingham.ac.uk/id/eprint/35795

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