Exploiting the plasticity of primary and secondary response mechanisms in artificial immune systems

Greensmith, Julie and Jackson, Andrew M. and Spendlove, Ian (2016) Exploiting the plasticity of primary and secondary response mechanisms in artificial immune systems. In: Genetic and Evolutionary Computation Conference (2016), 20-24 Jul 2016, Denver, USA.

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Abstract

One of the key properties of the human immune system is to detect the presence of pathogens, and as such there are numberous immune algorithm which perform anomaly detection and pattern recognition. An additional facet of the human immune system is that an appropriate effector response is generated upon the detection of a pathogen - a process termed the primary response. Additionally the human immune system has the ability to remember the appropriate response to a particular pathogen - the secondary response. The complex orchestration of both the primary and secondary responses are highly dynamic - described in immunological terms as plastic. In this paper we present an overview of the the exact mechanisms of the generation of a T-helper cell primary response and the mechanisms by which it instructs secondary responses and discuss how this can be computationally useful in artificial immune system development.

Item Type: Conference or Workshop Item (Paper)
Additional Information: Published in: Proceedings of the 2016 on Genetic and Evolutionary Computation Conference Companion pp. 7-8, ACM : New York, ©2016. ISBN: 9781450343237, doi: 10.1145/2908961.2908962
Keywords: Artificial Immune Systems; Primary and Secondary Response
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine
University of Nottingham UK Campus > Faculty of Science > School of Computer Science
Identification Number: https://doi.org/10.1145/2908961.2908962
Depositing User: Greensmith, Julie
Date Deposited: 09 Aug 2016 07:36
Last Modified: 26 Sep 2016 14:56
URI: http://eprints.nottingham.ac.uk/id/eprint/35766

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