Effect of simvastatin on vascular tone in porcine coronary artery: potential role of the mitochondria
Almukhtar, H. and Garle, M.J. and Smith, P.A. and Roberts, R.E. (2016) Effect of simvastatin on vascular tone in porcine coronary artery: potential role of the mitochondria. Toxicology and Applied Pharmacology, 305 . pp. 176-185. ISSN 0041-008X
Statins induce acute vasorelaxation which may contribute to the overall benefits of statins in the treatment of cardiovascular disease. The mechanism underlying this relaxation is unknown. As statins have been shown to alter mitochondrial function, in this study we investigated the role of mitochondria in the relaxation to simvastatin.
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