Drug-like antagonists of P2Y receptors — from lead identification to drug developmentTools Conroy, Sean, Kindon, Nicholas, Kellam, Barrie and Stocks, Michael (2016) Drug-like antagonists of P2Y receptors — from lead identification to drug development. Journal of Medicinal Chemistry . ISSN 1520-4804 Full text not available from this repository.
Official URL: http://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5b01972
AbstractP2Y receptors are expressed in virtually all cells and tissue types and mediate an astonishing array of biological functions, including platelet aggregation, smooth muscle cell proliferation, and immune regulation. The P2Y receptors belong to the G protein-coupled receptor superfamily and are composed of eight members encoded by distinct genes that can be subdivided into two groups on the basis of their coupling to specific G-proteins. Extensive research has been undertaken to find modulators of P2Y receptors, although to date only a limited number of small-molecule P2Y receptor antagonists have been approved by drug/medicines agencies. This Perspective reviews the known P2Y receptor antagonists, highlighting oral drug-like receptor antagonists, and considers future opportunities for the development of small molecules for clinical evaluation.
Actions (Archive Staff Only)
|
Tools
Tools
