Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety

Cottam, William J. and Condon, Laura and Alshuft, Hamza and Reckziegel, Diane and Auer, Dorothee P. (2016) Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety. NeuroImage: Clinical, 12 . pp. 269-276. ISSN 2213-1582

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Abstract

Functional magnetic resonance imaging studies (fMRI) have transformed our understanding of central processing of evoked pain but the typically used block and event-related designs are not best suited to the study of ongoing pain. Here we used arterial spin labelling (ASL) for cerebral blood flow mapping to characterise the neural correlates of perceived intensity of osteoarthritis (OA) pain and its interrelation with negative affect. Twenty-six patients with painful knee OA and twenty-seven healthy controls underwent pain phenotyping and ASL MRI at 3T. Intensity of OA pain correlated positively with blood flow in the anterior mid-cingulate cortex (aMCC), subgenual cingulate cortex (sgACC), bilateral hippocampi, bilateral amygdala, left central operculum, mid-insula, putamen and the brainstem. Additional control for trait anxiety scores reduced the pain-CBF association to the aMCC, whilst pain catastrophizing scores only explained some of the limbic correlations. In conclusion, we found that neural correlates of reported intensity of ongoing chronic pain intensity mapped to limbic-affective circuits, and that the association pattern apart from aMCC was explained by trait anxiety thus highlighting the importance of aversiveness in the experience of clinical pain.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/791966
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences
Identification Number: https://doi.org/10.1016/j.nicl.2016.06.022
Depositing User: Eprints, Support
Date Deposited: 29 Jul 2016 12:51
Last Modified: 04 May 2020 17:53
URI: http://eprints.nottingham.ac.uk/id/eprint/35565

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