The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research

Bath, Philip M.W. and Appleton, Jason P. and Sprigg, Nikola (2016) The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research. International Journal of Stroke . ISSN 1747-4949

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Abstract

The prevention of recurrent events after ischaemic stroke and transient ischaemic attack is well established and based on lifestyle changes, antithrombotics, statins, antihypertensives and carotid surgery. The international IRIS trial assessed whether pioglitazone, a glucose-lowering insulin-sensitizing drug, would reduce recurrent vascular events in patients with ischaemic stroke or transient ischaemic attack. After 4.8 years, pioglitazone therapy was associated with reduced vascular events and new diabetes, and an increase in weight, oedema and bone fractures. Pioglitazone may add to the strategies for preventing further events in patients with stroke or transient ischaemic attack.

Item Type: Article
Keywords: Prevention, Ischaemic Stroke, Clinical Trial, Stroke, Treatment, Vascular Events
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Division of Clinical Neuroscience
Identification Number: https://doi.org/10.1177/1747493016660099
Depositing User: Eprints, Support
Date Deposited: 28 Jul 2016 08:17
Last Modified: 22 Sep 2016 17:57
URI: http://eprints.nottingham.ac.uk/id/eprint/35498

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